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Acte d\'opposition à la saisie exécution

Glossary entry

français term or phrase:

vancomycinémie

anglais translation:

vancomycinemia or level of vancomycin in blood

Added to glossary by Drmanu49
Feb 12, 2018 19:30
6 yrs ago
français term

vancomycinémie

français vers anglais Médecine Médecine (général) Infective endocarditis
Dear all,

I have found "vancomycinemia" on various sites, but am not convinced. Also, what does this actually mean?


Here is the context:

Un sepsis, une bactériémie polymicrobienne, une vancomycinémie initiale; 15 mg/ml ou un traitement empirique par daptomycine en monothérapie étaient associés à l’échec du traitement conservateur
Proposed translations (anglais)
4 +1 vancomycinemia or level of vancomycin in blood
3 +4 initial serum vancomycin levels
4 vancomycin blood level
5 -1 vancomycin poisoning due to overload
3 -1 excessive vancomycin in blood
Change log

Feb 17, 2018 19:10: Drmanu49 Created KOG entry

Discussion

liz askew (asker) Feb 16, 2018:
Hello there! Thanks for everybody's comments, to be honest I delivered this a few days ago, so I don't know if this was a retrospective study as I upload the document, and the client keeps it. In any case, I used Drmanu's answer as it was the one there at the time, also it makes sense.
https://labtestsonline.org.uk/tests/vancomycin
Drmanu49 Feb 13, 2018:
Maybe Liz can tell us if this was a retrospective study. Of course a levl below the target could explain the failure but it is also compared to empirical daptomycin treatment without more information...
Anne Schulz Feb 13, 2018:
Mais pourquoi - doesn't this text list risk factors for failure of conservative (antibiotic) treatment? If a vancomycin level at or above 15 mg/ml is the target (I agree with you on that), then a level below that (< 15 mg/ml) may reasonably be expected to be a factor predicting failure of therapy, wouldn't it?
Drmanu49 Feb 13, 2018:
Once again 15 mg/ml is the usual target for first line vancomycin. No reason for a > or < but maybe ->. I suspect that this (retrospective?) study concerned more than one patient/ episode since daptomycin was also used and that the conservative treatment failed.
Anne Schulz Feb 13, 2018:
I was referring to Helen Genevier's comment to Sue Davis' answer.
Catherine Earle Feb 13, 2018:
Love to see this....where are Helen's comments?
Anne Schulz Feb 13, 2018:
I am fairly sure that Helen hit the nail right on the head: the ";" should be a less-than sign, and suddenly the whole thing makes sense ;-)
Herbmione Granger Feb 13, 2018:
with all due respect (which I have not received) I'm pretty sure it refers to the addition of vancomycin to the bloodstream or treatment with vancomycin. In none of my references does simply vancomycin blood level make sense. My earlier comments were simply dismissed.
Drmanu49 Feb 12, 2018:
The source text in no way cites drug (vancomycin) toxicity. The question was what does vancomycinémie mean and the answer was given.
Catherine Earle Feb 12, 2018:
Yes, sktrans, but, for example, "kalemia" is almost out of use, and the word is now used almost exclusively with the prefixes "hyper" and "hypo", again, denoting a disorder. See:https://www.medicinenet.com/script/main/art.asp?
articlekey=33655. Natremia, while currently in use, is also very frequently used with the same prefixes, so again, a disorder.
sktrans Feb 12, 2018:
"emia" also means "blood level" as in: natremia, kalemia
Natremia - Medical Definition from MediLexicon
www.medilexicon.com/dictionary/58851

natremia [nā-trē′mē-ă, nā′trē-ē′mē-ă] Type:Term. Definitions 1. The presence of sodium in the blood.
It becomes pathological if it is hypo- or hypernatremia.
Catherine Earle Feb 12, 2018:
Actually, the text does specifically cite toxicity. Sepsis is bacterial toxicity. One of the anti-biotics commonly used as monotherapeutic treatment of sepsis is piperacillin-tazobactam . Piperacillin-tazobactam is also frequently used in combination with vancomycin (see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023302/) and this often results in neprotoxicity. In addition, as Phil points out, there is a semi-colon separating the measured blood level (which may or may not be a vanco blood level) from the previous text. The measurement given is therefore not necessarily associated with the blood level of vanco.
Liz, it may also be of interest to you to know that bacteremia is associated with endocarditis (see: https://study.com/academy/lesson/bacteremia-definition-sympt...
Finally, I feel it is almost unnecessary to point out to a "room" full of linguists that the suffix "-emia" designates a blood disorder, with "anemia" and "leukemia" being 2 other examples.
I stand by my translation recommendation.
Drmanu49 Feb 12, 2018:
Nothing strange for a sequential report Phil. vancomycinémie is the initial treatment for the two infectious problems. And certainly nothing points to toxicity but rather to the lack of treatment effectiveness.
philgoddard Feb 12, 2018:
I'm not a medic... ...and I also find the syntax and punctuation strange, but aren't the three things before the semicolon problems that need treatment? Doesn't that imply toxicity?
Drmanu49 Feb 12, 2018:
Nothing in the source sentence suggests toxicity, and 15 mg/ml is a usual target. Check my last ref.
Catherine Earle Feb 12, 2018:
While I respect your hematologist's opinion, Drmanu49, I persist in my choice of either my earlier translation, or a translation of "vancomycin toxicity". The literature on this subject is clear. An overload of vancomycin may lead to kidney dysfunction, and even failure, in as much as 30% of patients who are being treated for an underlying sepsis (I believe it is endocarditis in the present case) and have previously received treatment with more conservative drugs. Here is another article on the subject, also from 2017: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023302/. You will see that the measurment of vancomycin levels in the blood is indeed part of the diagnostic process for this problem, but the word itself names the disorder, not a measurement indicating the disorder. In the literature, vancomycinemia is always associated with a word such as "toxicity" or "poisoning" or "overload". Finally, I find my source here, the NCBI, to be as creditable as the university medical center at Grenoble.
Drmanu49 Feb 12, 2018:
Polymicrobial bacteremia but also multibacterial/polybacterial bacteremia
Herbmione Granger Feb 12, 2018:
how would the Drs translate bactériémie polymicrobienne?
Drmanu49 Feb 12, 2018:
I just called Dr JP Brion CHU Grenoble who is a specialist. He confirms my answer and says it is synonymous to taux sanguin de vancomycine.
Herbmione Granger Feb 12, 2018:
another reference http://www.jle.com/download/jpc-269995-efficience_du_monitor...
Les différents moyens, humains et matériels, mis en oeuvre
sont évalués. Le coût des prélèvements et dosages est lié
à l’utilisation d’un corps d’un système Vacutainer®
(0,42 cts 5), d’aiguille à prélèvements (31,77 cts 5), de
tubes à prélèvements pour dosages (créatininémie
(8,93 cts 5) et vancomycine (8,84 cts 5)), l’acte infirmier
(2,90 5). Le coût d’une vancomycinémie est de 18,79 5,
celui d’une créatininémie de 2,70 5.
Drmanu49 Feb 12, 2018:
That is what I said, blood level of vancomycin.
Herbmione Granger Feb 12, 2018:
After seeing some French references, I think it is the injected vancomycin. http://huep.aphp.fr/wp-content/blogs.dir/107/files/2013/02/A...
Drmanu49 Feb 12, 2018:
Not toxicity just blood level of vancomycin.
philgoddard Feb 12, 2018:
Vancomycin toxicity?

Proposed translations

+1
15 minutes
Selected

vancomycinemia or level of vancomycin in blood

[Vancomycin poisoning successfully treated with intermittent ... - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29295766 - Traduire cette page
de J Zaworski - ‎2017
30 déc. 2017 - The vancomycinemia was measured as high as 360mg/L (normal range: 15-35mg/L). We started an intermittent hemodialysis program to clear out the vancomycin. The vancomycinemia decreased below the treshold of our laboratory after the eighth session. Three supplementary sessions were needed ...

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Note added at 15 minutes (2018-02-12 19:46:23 GMT)
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www.journaltocs.ac.uk › Browse by Publisher

The vancomycinemia decreased below the treshold of our laboratory after the eighth session. Three supplementary ..... in 157 patients (48%). Among them, during the first three months of treatment, 55 (35%) present hypertension according to the oncological definition and 59 (38%) according to the classical definition; .

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Note added at 19 minutes (2018-02-12 19:49:55 GMT)
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Intérêt du suivi thérapeutique et pharmacologique de la Vancomycine ...
dspace.univ-tlemcen.dz/.../Interet-du-suivi-therapeutique-et-pharmacologique-de-la-V...

Figure 11 : Corrélation entre la clairance de la créatinine et les taux résiduels de la vancomycine. 50. Figure 12 : Corrélation entre la clairance de la créatinine et les pics ..... Chez les bactéries à Gram positif, elle agit au niveau du ... (Okamoto G et al ,2007) un monitorage de la fonction rénale et de vancomycinémie.

--------------------------------------------------
Note added at 2 heures (2018-02-12 21:35:18 GMT)
--------------------------------------------------

I just called Dr JP Brion CHU Grenoble who is a specialist. He confirms my answer and says it is synonymous to taux sanguin de vancomycine.

--------------------------------------------------
Note added at 2 heures (2018-02-12 22:25:47 GMT)
--------------------------------------------------

TRAITEMENT PAR VANCOMYCINE
erasmeinfo.ulb.ac.be/compendium/.../TRAITEMENT_PAR_VANCOMYCINE.doc

taux sanguins trop faibles, l'espace entre les injections doit être rapproché.. Dosage : A la vallée (avant l'injection suivante) et réalisé 1-2 fois par semaine. Objectif : concentration entre 10 et 15 µg/mL. AUX SOINS INTENSIFS : Posologie : Habituellement administrée en perfusion continue. 15 mg/kg dose de charge puis ...
Peer comment(s):
neutral philgoddard : (a) I'm not convinced there's such a word in English; (b) your first reference says "vancomycin poisoning", which supports my suggestion of "toxicity".
16 minutes
Read my lasr ref Phil. It may be toxic if too high but may decrease below detectable levels (my first ref).
agree Anne Schulz : vancomycin blood levels – you were first
23 heures
Thank you Anne.
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "I think I eventually put "level of vancomycin in the blood"... Thank you!"
+4
43 minutes

initial serum vancomycin levels

vancomycin levels are measured to regulate treatment and monitor efficacy

http://www.cumc.columbia.edu/dept/id/downloads/Vancomycin_5-...

Determine maintenance dose using the following
Each maintenance dose (approx. 12 to 15 mg/kg) should be administered at the dosing interval recommended for a
patient’s CrCL. Maximum initial dose is 1500 mg every 12 hours until serum concentration monitoring indicates the
need for higher dosing. Utilize recommended infusion rates to minimize development of “Red Man’s Syndrome.”


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Note added at 47 mins (2018-02-12 20:18:30 GMT)
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291340/

Recommendations for monitoring serum vancomycin concentrations
Christopher W. James, PHARMDcorresponding author1 and Cheryle Gurk-Turner, RPH1
Author information ► Copyright and License information ►
Vancomycin is a glycopeptide antibiotic that has been used for the treatment of infections due to gram-positive microorganisms since 1956 (1). Shortly thereafter, Geraci et al described 2 cases of irreversible ototoxicity secondary to vancomycin therapy, with serum concentrations ranging from 80 to 100 mg/L (2). Based on this, the authors recommended therapeutic drug monitoring of vancomycin to reduce the risk of ototoxicity. The practice of routine therapeutic drug monitoring originated when the guidelines for monitoring peak and trough concentrations of aminoglycosides were applied to vancomycin therapy, based on similarities in pharmacokinetic and toxicity profiles (e.g., nephrotoxicity and ototoxicity) (3–5). However, the pharmacodynamics of vancomycin, which exhibits concentration-independent activity, are quite different from those of the aminoglycosides, which display concentration-dependent killing (5), (6). It is interesting to note that the manufacturer makes no recommendations regarding therapeutic drug monitoring (7). Therefore, the need for therapeutic drug monitoring in patients receiving vancomycin is controversial. This article examines the available evidence on the efficacy and toxicity of different concentrations of vancomycin and presents guidelines for therapeutic drug monitoring in patients receiving vancomycin therapy.
Peer comment(s):
neutral Drmanu49 : That is my answer more or less.
1 heure
agree Rachel Fell : This seems to be right in the context
3 heures
Thanks Rachel!
agree Helen Genevier : And I suspect that the ";" in Liz's excerpt should be "<" or maybe even ">"
15 heures
Thanks Helen!
agree Bertrand Leduc
15 heures
Thanks Bertrand!
agree Catherine Earle : Yes, I agree, too, and I have found a reference article for this usage: Interet-du-suivi-therapeutique-et-pharmacologique-de-la-Vancomycine-en-periode-pediatrique, which I did not see yesterday.
1 jour 1 heure
Something went wrong...
1 heure

vancomycin blood level

Vancomycin blood levels
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 10-20 µg/mL (15-20 µg/mL for complicated infections).
Vancomycin Level: Reference Range, Interpretation ...
emedicine.medscape.com/article/2090484-overview
Peer comment(s):
neutral Drmanu49 : That is my answer more or less.
39 minutes
Mine is more common in English! I also gave the dosage and you followed suit.
Something went wrong...
-1
1 heure

vancomycin poisoning due to overload

Peer comment(s):
disagree Drmanu49 : not poisoning.
33 minutes
Something went wrong...
-1
11 minutes

excessive vancomycin in blood

http://europepmc.org/articles/PMC2887149
Potential AKI risk factors were also noted: use of nephrotoxic antibiotics (aminoglycosides, glycopeptides), inappropriate administration (aminoglycosides injection whereas plasma measurement was superior to 2 μg/ml, vancomycinemia superior to 30 μg/ml),

https://labtestsonline.org/tests/vancomycin
excessive concentrations of vancomycin must be avoided because high levels can result in serious side effects, specifically damage to hearing (ototoxicity) and kidney damage (nephrotoxicity)

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Note added at 23 mins (2018-02-12 19:53:35 GMT)
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I'm not so sure. Going by usage.
https://medworm.com/476021146/vancomycin-poisoning-successfu...
We report a case of a 43 years old man who was intoxicated by a 25g vancomycin overload. An anuric acute renal failure rapidly occured. The vancomycinemia was measured as high as 360mg/L (normal range: 15-35mg/L). We started an intermittent hemodialysis program to clear out the vancomycin. The vancomycinemia decreased below the treshold of our laboratory after the eighth session. Three supplementary sessions were needed because of a persistant oliguria.

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Note added at 15 hrs (2018-02-13 11:08:01 GMT)
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Would like to change my answer to "vancomycin loading" as the translation of vancomycinémie. Not sure it is being used properly, but it would be a "traitement." However, seems like the units of "15 mg/ml" should be mcg/mL and should refer to the trough concentration.

https://www.universityhealthsystem.com/~/media/files/clinica...
Initial Dosing of Vancomycin
Load: 15 – 20 mg/kg X 1
Maintenance: 500 mg – 1 g after each dialysis
In patients receiving IHD give the “load” dose now followed by “maintenance” dose after subsequent dialysis
Example: Patient is on 1g every 12 hrs with a trough of 30mcg/mL. My desired trough is 15 mcg/mL. What is the recommended daily vancomycin dose to attain this level?

http://huep.aphp.fr/wp-content/blogs.dir/107/files/2013/02/A...
dose initiale vancomycine 15mg/kg puis seringue éléctrique 15mg/kg/j à adapter avec
vancomycinémie journalière au début
Peer comment(s):
disagree Drmanu49 : why excessive?
5 minutes
Something went wrong...
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