коэффициент индивидуальной вариабельности

English translation: intrasubject/intrapatient coefficient of variation

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Russian term or phrase:коэффициент индивидуальной вариабельности
English translation:intrasubject/intrapatient coefficient of variation
Entered by: 5555555 (X)

18:20 Oct 20, 2017
Russian to English translations [PRO]
Medical - Medical (general) / Clinical Trial
Russian term or phrase: коэффициент индивидуальной вариабельности
Расчет размера выборки основан на величине ***коэффициента индивидуальной вариабельности*** для Cmax, который, по данным ранее проведенного фармакокинетического исследования составил xx%
5555555 (X)
United States
Local time: 08:49
intrasubject/intrapatient coefficient of variation
Explanation:
Example from FDA documentation:

[PPT]
Demonstrating Bioequivalence for Highly Variable Drugs - FDA
https://www.fda.gov/ohrms/dockets/ac/.../4034S2_02_DiLiberti...
... of absorption shows large dose-to-dose variability within the same patient ... those drugs whose intrapatient coefficient of variation (Cmax and/or AUC) is ...

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Note added at 1 hr (2017-10-20 19:37:14 GMT)
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Oh, sorry, Kimberly, I took this from Google:
http://tinyurl.com/ybo6faev (it is 5th hit)

But I'll make some more search at FDA

--------------------------------------------------
Note added at 1 hr (2017-10-20 19:44:40 GMT)
--------------------------------------------------

Looks like this specific document has been removed, but here are other links:

"intrasubject coefficient of variation"http://tinyurl.com/y8dz4uw6
"intrapatient coefficient of variation" http://tinyurl.com/yaeeh85b

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Note added at 1 hr (2017-10-20 19:48:25 GMT)
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Pharmacokinetics in Drug Development: Clinical Study Design and ...
Peter L. Bonate, Danny R. Howard - ‎2005 - Medical
The intrasubject coefficient of variation, CVE is estimated by cv. ...
http://tinyurl.com/y87mguaz
Selected response from:

Natalie
Poland
Local time: 17:49
Grading comment
The PowerPoint presentation by Charles E. DiLiberti was especially helpful. Thank you Natalie.
4 KudoZ points were awarded for this answer



Summary of answers provided
5 +1intrasubject/intrapatient coefficient of variation
Natalie
3individual variabilty ratio
Oleg Lozinskiy
2сoefficient of individual variability
Ellen Kraus


  

Answers


12 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5
сoefficient of individual variability


Explanation:
that´s what it says

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Note added at 18 Min. (2017-10-20 18:39:06 GMT)
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or coefficient of individual Variation:


Wissenschaftliche Artikel zu coefficient of individual variability


… -channel blockers on within-individual variability in … - ‎Rothwell - Zitiert von: 541

… the role of intra-individual variability in obscuring the … - ‎Liu - Zitiert von: 581

The effect of feeding hierarchy on individual variability … - ‎McCarthy - Zitiert von: 316




Suchergebnisse








Intra-individual Variability as a Measure of Information Processing ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883002/ -These between-group differences were not found when the coefficient of variation, a more coarse measure of within-subject variability, was used. Intra-individual ...

Ellen Kraus
Austria
Local time: 17:49
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 128
Login to enter a peer comment (or grade)

9 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
individual variabilty ratio


Explanation:
Как видим, так и переводим :-) Возможны варианты --> https://www.google.ru/search?newwindow=1&biw=1067&bih=749&tb...

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Note added at 19 мин (2017-10-20 18:39:36 GMT)
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Sorry for the typo: 'individual variabil<Ity ratio' - BUT... this is just to provide 'business opportunities' for the 'translation proofers/editors'...

Oleg Lozinskiy
Russian Federation
Local time: 18:49
Native speaker of: Native in RussianRussian
PRO pts in category: 271
Login to enter a peer comment (or grade)

44 mins   confidence: Answerer confidence 5/5 peer agreement (net): +1
intrasubject/intrapatient coefficient of variation


Explanation:
Example from FDA documentation:

[PPT]
Demonstrating Bioequivalence for Highly Variable Drugs - FDA
https://www.fda.gov/ohrms/dockets/ac/.../4034S2_02_DiLiberti...
... of absorption shows large dose-to-dose variability within the same patient ... those drugs whose intrapatient coefficient of variation (Cmax and/or AUC) is ...

--------------------------------------------------
Note added at 1 hr (2017-10-20 19:37:14 GMT)
--------------------------------------------------

Oh, sorry, Kimberly, I took this from Google:
http://tinyurl.com/ybo6faev (it is 5th hit)

But I'll make some more search at FDA

--------------------------------------------------
Note added at 1 hr (2017-10-20 19:44:40 GMT)
--------------------------------------------------

Looks like this specific document has been removed, but here are other links:

"intrasubject coefficient of variation"http://tinyurl.com/y8dz4uw6
"intrapatient coefficient of variation" http://tinyurl.com/yaeeh85b

--------------------------------------------------
Note added at 1 hr (2017-10-20 19:48:25 GMT)
--------------------------------------------------

Pharmacokinetics in Drug Development: Clinical Study Design and ...
Peter L. Bonate, Danny R. Howard - ‎2005 - Medical
The intrasubject coefficient of variation, CVE is estimated by cv. ...
http://tinyurl.com/y87mguaz

Natalie
Poland
Local time: 17:49
Specializes in field
Native speaker of: Russian
PRO pts in category: 809
Grading comment
The PowerPoint presentation by Charles E. DiLiberti was especially helpful. Thank you Natalie.
Notes to answerer
Asker: Natalie, the link comes up as an error message. Can you give me an article title to search on FDA site or a tinyurl? Thank you very much.

Asker: This is perfect! Thank you Natalie!


Peer comments on this answer (and responses from the answerer)
agree  Evgeni Kushch: вот я особенно за intra; и еще within вижу, не знаю только насколько понятия тождественны
2 hrs
  -> Да-да, within тоже употребляется - спасибо!
Login to enter a peer comment (or grade)



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